法国巴黎某处共享办公室内，一名神秘杀手（迈克尔·法斯宾德 Michael Fassbender 饰）正静待猎物的到来。他外表冷酷，沉默寡言，内心则絮絮不止，一遍又一遍重复着作为杀手的准则，仿佛这样才能使他有所凭依，内心安定。然而即便如此，他准备了数日的刺杀却以失败告终。失手之后，杀手按照既定的路线迅速撤离，并在上线的安排下躲到多米尼加的家中暂避风头。谁知才刚踏上自家院落，他就嗅出了危险气息。原来在此之前，早已有两名杀手踏足此地，并将杀手的妻子（索菲·夏洛特 Sophie Charlotte 饰）殴至重伤。杀手恼羞不已，他根据仅有的线索，一路追查幕后的指使和参与者。 一旦失手，万劫不复，此时此刻他有切身体会……
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