某医学院心理学系大一新生宋朵朵（游乐儿 饰），不知为何近一段时间经常做一个三个带着面具之人请笔仙的恐怖噩梦，醒着时也偶尔会看见溺死的女鬼。朵朵和好友白妮（杨曼玉 饰）参加了一个名为鬼话夜谭的社团，这一天她和罗京（陶醉 饰）、齐小川（陈炳强 饰）等人接收了社团的新任务，那就是前往废弃的医学院教学楼寻找白色头骨。夜幕降临，朵朵和白妮相约来到这个恐怖的所在，据说当年有一位学姐曾在此自杀，尸体泡在了福尔马林里，自此之后该校舍闹鬼的说法便不胫而走。在寻找头骨的过程中，朵朵遭遇白衣女鬼，从而受到莫大惊吓。考试前夕，几位好朋友相约来到南岛解压，而各种遭遇促使着他们请来笔仙搜索真相……
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