从小品学兼优、美丽干练的米雪（范冰冰 饰）对人生有着极好的规划，如今她身为某大型广告策划公司主管，事业顺风顺水，春风得意。可就在一个多月前盛大的生日派对过后，米雪竟意外发现自己有孕在身。一切的一切都指向了此前那个狂欢到极点、酗酒到断片的生日派对，在五十多名到场男性中，业已离婚的钻石男公司老板周毕安（丹尼尔•海尼 饰）、爱恋米雪的青年下属张童宇（李治廷 饰）、健壮帅气的干儿子林智博（蒋劲夫 饰）以及卖海鲜酱发财的暴发户陆大虎（黎明 饰）。 在闺蜜林薇薇（吴佩慈 饰）的参谋下，米雪手足无措地迎来了人生中最跌宕起伏的时刻……
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