在人间之外的天堂与地狱之战绵延不绝，双方都在为自己争取强力的战士。中情局特工西蒙斯（迈克尔·加·怀特 Michael Jai White 饰）厌倦了杀戮的任务，向上司威恩（马丁·辛 Martin Sheen 饰）提出退出，岂料却在朝鲜执行任务时被威恩害死。坠入地狱的西蒙斯与恶魔马里波吉亚达成协议，同意为它统率地狱军队来换得再生报仇的机会。被恶魔雪藏五年的西蒙斯再生回到人间，以再生侠之名示人，并在恶魔走狗——小丑的引领下向威恩复仇。此时研究生化武器着魔的威恩试图统治世界，而他的死亡会引发全球陷入生化灾难。为了复仇的西蒙斯能置全人类的安危于不顾么？
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